mTOR and Neuronal Cell Cycle Re-entry: How Impaired Brain Insulin Signaling Promotes Alzheimer's Disease

A major obstacle to pre-symptomatic diagnosis and disease-modifying therapy for Alzheimer's disease (AD) is inadequate understanding of molecular mechanisms of AD pathogenesis. For example, impaired brain insulin signaling is an AD hallmark, but whether and how it might contribute to the synapt...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement
Main Authors: Norambuena, Andrés, Wallrabe, Horst, McMahon, Lloyd, Silva, Antonia, Swanson, Eric, Khan, Shahzad S., Baerthlein, Daniel, Kodis, Erin, Oddo, Salvatore, Mandell, James W., Bloom, George S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318248/
https://ncbi.nlm.nih.gov/pubmed/27693185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.08.015
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