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mTOR hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer’s disease pathology
High sugar consumption and diabetes increase the risk of developing Alzheimer’s disease (AD) by unknown mechanisms. Using an animal model of AD, here we show that high sucrose intake induces obesity with changes in central and peripheral insulin signaling. These pre-diabetic changes are associated w...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973159/ https://ncbi.nlm.nih.gov/pubmed/24411482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.12.006 |
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