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Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization
Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting memb...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5317004/ https://ncbi.nlm.nih.gov/pubmed/28218274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42481 |
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