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Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization

Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting memb...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Degani-Katzav, Nurit, Klein, Moshe, Har-Even, Moran, Gortler, Revital, Tobi, Ruthi, Paas, Yoav
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317004/
https://ncbi.nlm.nih.gov/pubmed/28218274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42481
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