Probing Pore Constriction in a Ligand-gated Ion Channel by Trapping a Metal Ion in the Pore upon Agonist Dissociation

Eukaryotic pentameric ligand-gated ion channels (pLGICs) are receptors activated by neurotransmitters to rapidly transport ions across cell membranes, down their electrochemical gradients. Recent crystal structures of two prokaryotic pLGICs were interpreted to imply that the extracellular side of th...

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Main Authors: Pittel, Ilya, Witt-Kehati, Dvora, Degani-Katzav, Nurit, Paas, Yoav
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Molecular Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924088/
https://ncbi.nlm.nih.gov/pubmed/20466725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102327
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