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Probing Pore Constriction in a Ligand-gated Ion Channel by Trapping a Metal Ion in the Pore upon Agonist Dissociation

Eukaryotic pentameric ligand-gated ion channels (pLGICs) are receptors activated by neurotransmitters to rapidly transport ions across cell membranes, down their electrochemical gradients. Recent crystal structures of two prokaryotic pLGICs were interpreted to imply that the extracellular side of th...

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Detalhes bibliográficos
Main Authors: Pittel, Ilya, Witt-Kehati, Dvora, Degani-Katzav, Nurit, Paas, Yoav
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924088/
https://ncbi.nlm.nih.gov/pubmed/20466725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102327
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