Probing Pore Constriction in a Ligand-gated Ion Channel by Trapping a Metal Ion in the Pore upon Agonist Dissociation

Eukaryotic pentameric ligand-gated ion channels (pLGICs) are receptors activated by neurotransmitters to rapidly transport ions across cell membranes, down their electrochemical gradients. Recent crystal structures of two prokaryotic pLGICs were interpreted to imply that the extracellular side of th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pittel, Ilya, Witt-Kehati, Dvora, Degani-Katzav, Nurit, Paas, Yoav
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924088/
https://ncbi.nlm.nih.gov/pubmed/20466725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102327
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