Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find that intratumoral therapy with Newcastle disease...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zamarin, Dmitriy, Holmgaard, Rikke B., Ricca, Jacob, Plitt, Tamar, Palese, Peter, Sharma, Padmanee, Merghoub, Taha, Wolchok, Jedd D., Allison, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316835/
https://ncbi.nlm.nih.gov/pubmed/28194010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14340
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