miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal

Mice harboring a G12D activating Kras mutation are among the most heavily studied models in the field of pancreatic adenocarcinoma (PDAC) research. miRNAs are differentially expressed in PDAC from patients and mouse models of PDAC. To better understand the relationship that Kras activation has on mi...

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Veröffentlicht in:Funct Integr Genomics
Hauptverfasser: Azevedo-Pouly, Ana Clara P., Sutaria, Dhruvitkumar S., Jiang, Jinmai, Elgamal, Ola A., Amari, Foued, Allard, David, Grippo, Paul J., Coppola, Vincenzo, Schmittgen, Thomas D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316511/
https://ncbi.nlm.nih.gov/pubmed/27541609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10142-016-0512-1
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