Knockout of Acinar Enriched microRNAs in Mice Promote Duct Formation But Not Pancreatic Cancer

The pancreatic acinar-enriched miR-216a, miR-216b and miR-217 are encoded within the miR217HG. These miRNAs have been purported to play a tumor suppressive role as their expression is reduced in both human and mouse pancreatic ductal adenocarcinoma (PDAC). To examine this possibility, we generated i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sutaria, Dhruvitkumar S., Jiang, Jinmai, Azevedo-Pouly, Ana Clara, Wright, Lais, Bray, Julie A., Fredenburg, Kristianna, Liu, Xiuli, Lu, Jun, Torres, Carolina, Mancinelli, Georgina, Grippo, Paul J., Coppola, Vincenzo, Schmittgen, Thomas D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668398/
https://ncbi.nlm.nih.gov/pubmed/31367007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47566-x
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