Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineered to produce EVs expressing a lysosomal associated...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:J Extracell Vesicles
Główni autorzy: Sutaria, Dhruvitkumar S., Jiang, Jinmai, Elgamal, Ola A., Pomeroy, Steven M., Badawi, Mohamed, Zhu, Xiaohua, Pavlovicz, Ryan, Azevedo-Pouly, Ana Clara P., Chalmers, Jeffrey, Li, Chenglong, Phelps, Mitch A., Schmittgen, Thomas D.
Format: Artigo
Język:Inglês
Wydane: Taylor & Francis 2017
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505005/
https://ncbi.nlm.nih.gov/pubmed/28717424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2017.1333882
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