Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineered to produce EVs expressing a lysosomal associated...

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Bibliografske podrobnosti
izdano v:J Extracell Vesicles
Main Authors: Sutaria, Dhruvitkumar S., Jiang, Jinmai, Elgamal, Ola A., Pomeroy, Steven M., Badawi, Mohamed, Zhu, Xiaohua, Pavlovicz, Ryan, Azevedo-Pouly, Ana Clara P., Chalmers, Jeffrey, Li, Chenglong, Phelps, Mitch A., Schmittgen, Thomas D.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505005/
https://ncbi.nlm.nih.gov/pubmed/28717424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2017.1333882
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