Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineered to produce EVs expressing a lysosomal associated...

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Detalles Bibliográficos
Publicado en:J Extracell Vesicles
Main Authors: Sutaria, Dhruvitkumar S., Jiang, Jinmai, Elgamal, Ola A., Pomeroy, Steven M., Badawi, Mohamed, Zhu, Xiaohua, Pavlovicz, Ryan, Azevedo-Pouly, Ana Clara P., Chalmers, Jeffrey, Li, Chenglong, Phelps, Mitch A., Schmittgen, Thomas D.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505005/
https://ncbi.nlm.nih.gov/pubmed/28717424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2017.1333882
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