Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy and disposition. However, as most EVs under evaluation are derived from human cells, they may elicit immune response...

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書目詳細資料
發表在:J Extracell Vesicles
Main Authors: Zhu, Xiaohua, Badawi, Mohamed, Pomeroy, Steven, Sutaria, Dhruvitkumar S., Xie, Zhiliang, Baek, Alice, Jiang, Jinmai, Elgamal, Ola A., Mo, Xiaokui, Perle, Krista La, Chalmers, Jeffrey, Schmittgen, Thomas D., Phelps, Mitch A.
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505007/
https://ncbi.nlm.nih.gov/pubmed/28717420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2017.1324730
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