Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy and disposition. However, as most EVs under evaluation are derived from human cells, they may elicit immune response...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Extracell Vesicles
Autori principali: Zhu, Xiaohua, Badawi, Mohamed, Pomeroy, Steven, Sutaria, Dhruvitkumar S., Xie, Zhiliang, Baek, Alice, Jiang, Jinmai, Elgamal, Ola A., Mo, Xiaokui, Perle, Krista La, Chalmers, Jeffrey, Schmittgen, Thomas D., Phelps, Mitch A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505007/
https://ncbi.nlm.nih.gov/pubmed/28717420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2017.1324730
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi