Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy and disposition. However, as most EVs under evaluation are derived from human cells, they may elicit immune response...

詳細記述

保存先:
書誌詳細
出版年:J Extracell Vesicles
主要な著者: Zhu, Xiaohua, Badawi, Mohamed, Pomeroy, Steven, Sutaria, Dhruvitkumar S., Xie, Zhiliang, Baek, Alice, Jiang, Jinmai, Elgamal, Ola A., Mo, Xiaokui, Perle, Krista La, Chalmers, Jeffrey, Schmittgen, Thomas D., Phelps, Mitch A.
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2017
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505007/
https://ncbi.nlm.nih.gov/pubmed/28717420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2017.1324730
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