Adenylyl Cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in Polycystic Liver Disease

BACKGROUND/AIMS: Genetic defects in Polycystins -1 or -2 (PC1 or PC2) cause polycystic liver disease associated with ADPKD (PLD-ADPKD). Progressive cyst growth is sustained by a cAMP-dependent Ras/ERK/HIFα pathway leading to increased autocrine/paracrine VEGF-A signalling. In PC2-defective cholangio...

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Detaylı Bibliyografya
Yayımlandı:J Hepatol
Asıl Yazarlar: Spirli, Carlo, Mariotti, Valeria, Villani, Ambra, Fabris, Luca, Fiorotto, Romina, Strazzabosco, Mario
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316496/
https://ncbi.nlm.nih.gov/pubmed/27826057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.10.032
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