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Altered Store Operated Calcium Entry Increases cAMP production and ERK1/2 phosphorylation in Polycystin-2 Defective Cholangiocytes
Mutations in polycystins (PC1 or PC2/TRPP2) cause progressive polycystic liver disease (PLD). In PC2 defective mice, cAMP/PKA-dependent activation of ERK/mTOR signaling stimulates cyst growth. We investigated the mechanisms connecting PC2 dysfunction to altered Ca(2+) and cAMP production and inappro...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2012
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272110/ https://ncbi.nlm.nih.gov/pubmed/21987453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24723 |
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