Altered Store Operated Calcium Entry Increases cAMP production and ERK1/2 phosphorylation in Polycystin-2 Defective Cholangiocytes

Mutations in polycystins (PC1 or PC2/TRPP2) cause progressive polycystic liver disease (PLD). In PC2 defective mice, cAMP/PKA-dependent activation of ERK/mTOR signaling stimulates cyst growth. We investigated the mechanisms connecting PC2 dysfunction to altered Ca(2+) and cAMP production and inappro...

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Detalhes bibliográficos
Main Authors: Spirli, Carlo, Locatelli, Luigi, Fiorotto, Romina, Morell, Carola M., Fabris, Luca, Pozzan, Tullio, Strazzabosco, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272110/
https://ncbi.nlm.nih.gov/pubmed/21987453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24723
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