c9orf72 Disease-Related Foci are Each Composed of One Mutant Expanded Repeat RNA

The chromosome 9 open reading frame 72 (c9orf72) gene contains a hexanucleotide (GGGGCC) repeat expansion responsible for many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mutant intronic RNA forms “foci” within nuclei, but the connection between transcript exp...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: Liu, Jing, Hu, Jiaxin, Ludlow, Andrew, Pham, Jackie, Shay, Jerry W., Rothstein, Jeffrey D., Corey, David R.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316317/
https://ncbi.nlm.nih.gov/pubmed/28132891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.12.018
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