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c9orf72 Disease-Related Foci are Each Composed of One Mutant Expanded Repeat RNA

The chromosome 9 open reading frame 72 (c9orf72) gene contains a hexanucleotide (GGGGCC) repeat expansion responsible for many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mutant intronic RNA forms “foci” within nuclei, but the connection between transcript exp...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Liu, Jing, Hu, Jiaxin, Ludlow, Andrew, Pham, Jackie, Shay, Jerry W., Rothstein, Jeffrey D., Corey, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316317/
https://ncbi.nlm.nih.gov/pubmed/28132891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.12.018
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