c9orf72 Disease-Related Foci are Each Composed of One Mutant Expanded Repeat RNA

The chromosome 9 open reading frame 72 (c9orf72) gene contains a hexanucleotide (GGGGCC) repeat expansion responsible for many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mutant intronic RNA forms “foci” within nuclei, but the connection between transcript exp...

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Detaylı Bibliyografya
Yayımlandı:Cell Chem Biol
Asıl Yazarlar: Liu, Jing, Hu, Jiaxin, Ludlow, Andrew, Pham, Jackie, Shay, Jerry W., Rothstein, Jeffrey D., Corey, David R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316317/
https://ncbi.nlm.nih.gov/pubmed/28132891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.12.018
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