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SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72

The expanded GGGGCC repeat mutation in the C9orf72 gene is the most common genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expansion is transcribed to sense and antisense RNA, which form RNA foci and bind cellular proteins. T...

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Dades bibliogràfiques
Publicat a:J Cell Sci
Autors principals: Malnar, Mirjana, Rogelj, Boris
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904093/
https://ncbi.nlm.nih.gov/pubmed/33495278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.256602
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