Drug Driven Synthetic Lethality: bypassing tumor cell genetics with a combination of Dbait and PARP inhibitors

PURPOSE: Cancer treatments using tumor defects in DNA repair pathways have shown promising results but are restricted to small subpopulations of patients. The most advanced drugs in this field are Poly(ADP-Ribose) Polymerase (PARP) inhibitors (PARPi), which trigger synthetic lethality in tumors with...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Jdey, Wael, Thierry, Sylvain, Russo, Christophe, Devun, Flavien, Abo, Muthana Al, Noguiez-Hellin, Patricia, Sun, Jian-Sheng, Barillot, Emmanuel, Zinovyev, Andrei, Kuperstein, Inna, Pommier, Yves, Dutreix, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315641/
https://ncbi.nlm.nih.gov/pubmed/27559053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1193
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