A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma()

Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break bait) molecules mimic DSBs and trap DNA repair proteins, thereby inhibiting repair of DNA damage induced by radiation therapy (RT). First, the cytotoxic...

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Autori principali: Biau, Julian, Devun, Flavien, Jdey, Wael, Kotula, Ewa, Quanz, Maria, Chautard, Emmanuel, Sayarath, Mano, Sun, Jian-Sheng, Verrelle, Pierre, Dutreix, Marie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212251/
https://ncbi.nlm.nih.gov/pubmed/25379020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.08.008
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