Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models

High grade glioma relapses occur often within the irradiated volume mostly due to a high resistance to radiation therapy (RT). Dbait (which stands for DNA strand break bait) molecules mimic DSBs and trap DNA repair proteins, thereby inhibiting repair of DNA damage induced by RT. Here we evaluate the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Oncol
Egile Nagusiak: Biau, Julian, Chautard, Emmanuel, Berthault, Nathalie, de Koning, Leanne, Court, Frank, Pereira, Bruno, Verrelle, Pierre, Dutreix, Marie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2019
Gaiak:
Oncology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593092/
https://ncbi.nlm.nih.gov/pubmed/31275862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00549
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