Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models

High grade glioma relapses occur often within the irradiated volume mostly due to a high resistance to radiation therapy (RT). Dbait (which stands for DNA strand break bait) molecules mimic DSBs and trap DNA repair proteins, thereby inhibiting repair of DNA damage induced by RT. Here we evaluate the...

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Biau, Julian, Chautard, Emmanuel, Berthault, Nathalie, de Koning, Leanne, Court, Frank, Pereira, Bruno, Verrelle, Pierre, Dutreix, Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593092/
https://ncbi.nlm.nih.gov/pubmed/31275862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00549
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