Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol

Increased DNA repair activity in cancer cells is one of their primary mechanisms of resistance to current radio- and chemotherapies. The molecule coDbait is the first candidate in a new class of drugs that target the double-strand DNA break repair pathways with the aim of overcoming these resistance...

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Detalhes bibliográficos
Main Authors: Schlegel, Anne, Buhler, Cyril, Devun, Flavien, Agrario, Céline, Urien, Saïk, Lokiec, François, Sun, Jian-Sheng, Dutreix, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411319/
https://ncbi.nlm.nih.gov/pubmed/23344149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.27
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