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Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.
Systematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways, known as between-pathway SL. However, recent gen...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2013-04-01
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| Colecção: | PLoS Computational Biology |
| Acesso em linha: | http://europepmc.org/articles/PMC3617211?pdf=render |
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