IGFBP2 activates the NF-κB pathway to drive epithelial-mesenchymal transition and invasive character in pancreatic ductal adenocarcinoma

The molecular basis underlying the particularly aggressive nature of pancreatic ductal adenocarcinoma (PDAC) still remains unclear. Here we report evidence that the insulin-like growth factor-binding protein IGFBP2 acts as a potent oncogene to drive its extremely malignant character. We found that e...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Gao, Song, Sun, Yan, Zhang, Xuebin, Hu, Limei, Liu, Yuexin, Chua, Corrine Yingxuan, Phillips, Lynette M., Ren, He, Fleming, Jason B., Wang, Huamin, Chiao, Paul J., Hao, Jihui, Zhang, Wei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315491/
https://ncbi.nlm.nih.gov/pubmed/27659045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0438
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