Kras(G12D)-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic ductal adenocarcinoma (PDAC). However, how NF-κB is activated in PDAC is not yet understood. Here, we report that pancreas-targeted IKK2/β inactivation inhibited NF-κB activation and PDAC development in Kras(...

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Detalhes bibliográficos
Main Authors: Ling, Jianhua, Kang, Ya’an, Zhao, Ruiying, Xia, Qianghua, Lee, Dung-Fang, Chang, Zhe, Li, Jin, Peng, Bailu, Fleming, Jason B., Wang, Huamin, Liu, Jinsong, Lemischka, Ihor R., Hung, Mien-Chie, Chiao, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360958/
https://ncbi.nlm.nih.gov/pubmed/22264792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.006
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