Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma (PDAC). However, the biochemical mechanisms underlying these double alterations remain unclear. Here we discover that NAD(P)H oxidase 4 (NOX4), an enzyme known to catalyse the oxidation of NAD(P)H, is upreg...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ju, Huai-Qiang, Ying, Haoqiang, Tian, Tian, Ling, Jianhua, Fu, Jie, Lu, Yu, Wu, Min, Yang, Lifeng, Achreja, Abhinav, Chen, Gang, Zhuang, Zhuonan, Wang, Huamin, Nagrath, Deepak, Yao, Jun, Hung, Mien-Chie, DePinho, Ronald A., Huang, Peng, Xu, Rui-Hua, Chiao, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333128/
https://ncbi.nlm.nih.gov/pubmed/28232723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14437
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados