Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma (PDAC). However, the biochemical mechanisms underlying these double alterations remain unclear. Here we discover that NAD(P)H oxidase 4 (NOX4), an enzyme known to catalyse the oxidation of NAD(P)H, is upreg...

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Pubblicato in:Nat Commun
Autori principali: Ju, Huai-Qiang, Ying, Haoqiang, Tian, Tian, Ling, Jianhua, Fu, Jie, Lu, Yu, Wu, Min, Yang, Lifeng, Achreja, Abhinav, Chen, Gang, Zhuang, Zhuonan, Wang, Huamin, Nagrath, Deepak, Yao, Jun, Hung, Mien-Chie, DePinho, Ronald A., Huang, Peng, Xu, Rui-Hua, Chiao, Paul J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333128/
https://ncbi.nlm.nih.gov/pubmed/28232723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14437
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