Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma (PDAC). However, the biochemical mechanisms underlying these double alterations remain unclear. Here we discover that NAD(P)H oxidase 4 (NOX4), an enzyme known to catalyse the oxidation of NAD(P)H, is upreg...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Ju, Huai-Qiang, Ying, Haoqiang, Tian, Tian, Ling, Jianhua, Fu, Jie, Lu, Yu, Wu, Min, Yang, Lifeng, Achreja, Abhinav, Chen, Gang, Zhuang, Zhuonan, Wang, Huamin, Nagrath, Deepak, Yao, Jun, Hung, Mien-Chie, DePinho, Ronald A., Huang, Peng, Xu, Rui-Hua, Chiao, Paul J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333128/
https://ncbi.nlm.nih.gov/pubmed/28232723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14437
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