IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway

Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent immunosuppressive activity, and play a pro-tumor role in pancreatic ductal adenocarcinoma (PDAC) biology. In this study, we investigated the role of the insulin-like growth factor binding protein 2 (IGFBP2) as a determin...

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發表在:Cancer Lett
Main Authors: Sun, Longhao, Zhang, Xuebin, Song, Qianqian, Liu, Liang, Forbes, Elizabeth, Tian, Weijun, Zhang, Zhixiang, Kang, Ya’an, Wang, Huamin, Fleming, Jason B., Pasche, Boris C., Zhang, Wei
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923838/
https://ncbi.nlm.nih.gov/pubmed/33309859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.12.008
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