Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells

Isopropyl methanesulfonate (IPMS) is the most potent genotoxic compound among methanesulfonic acid esters. The genotoxic potential of alkyl sulfonate esters is believed to be due to their alkylating ability of the O6 position of guanine. Understanding the primary repair pathway activated in response...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hashimoto, Kiyohiro, Sharma, Vyom, Sasanuma, Hiroyuki, Tian, Xu, Takata, Minoru, Takeda, Shunichi, Swenberg, James A., Nakamura, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312349/
https://ncbi.nlm.nih.gov/pubmed/27486975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10928
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