Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells

Elucidating the DNA repair pathways that are activated in the presence of genotoxic agents is critical to understand their modes of action. Although the DT40 cell-based DNA damage response (DDR) assay provides rapid and sensitive results, the assay cannot be used on genotoxic compounds that require...

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Publicado en:Mutagenesis
Autores principales: Hashimoto, Kiyohiro, Takeda, Shunichi, Swenberg, James A., Nakamura, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723676/
https://ncbi.nlm.nih.gov/pubmed/26085549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gev042
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