Efficacy of ATR inhibitors as single agents in Ewing sarcoma

Ewing sarcomas (ES) are pediatric bone tumors that arise from a driver translocation, most frequently EWS/FLI1. Current ES treatment involves DNA damaging agents, yet the basis for the sensitivity to these therapies remains unknown. Oncogene-induced replication stress (RS) is a known source of endog...

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Udgivet i:Oncotarget
Main Authors: Nieto-Soler, Maria, Morgado-Palacin, Isabel, Lafarga, Vanesa, Lecona, Emilio, Murga, Matilde, Callen, Elsa, Azorin, Daniel, Alonso, Javier, Lopez, Andres J., Nussenzweig, Andre, Fernandez-Capetillo, Oscar
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312273/
https://ncbi.nlm.nih.gov/pubmed/27577084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11643
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