Leukocyte TLR5 deficiency inhibits atherosclerosis by reduced macrophage recruitment and defective T-cell responsiveness

Toll-like receptors (TLR) provide a critical link between innate and adaptive immunity, both important players in atherosclerosis. Since evidence for the role of TLR5 is lacking, we aimed to establish this in the immune axis of atherosclerosis. We assessed the effect of the TLR5-specific ligand Flag...

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Publicat a:Sci Rep
Autors principals: Ellenbroek, Guilielmus H.J.M., van Puijvelde, Gijs H.M., Anas, Adam A., Bot, Martine, Asbach, Miriam, Schoneveld, Arjan, van Santbrink, Peter J., Foks, Amanda C., Timmers, Leo, Doevendans, Pieter A., Pasterkamp, Gerard, Hoefer, Imo E., van der Poll, Tom, Kuiper, Johan, de Jager, Saskia C.A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311952/
https://ncbi.nlm.nih.gov/pubmed/28202909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42688
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