Agonistic Anti-TIGIT Treatment Inhibits T Cell Responses in LDLr Deficient Mice without Affecting Atherosclerotic Lesion Development

OBJECTIVE: Co-stimulatory and co-inhibitory molecules are mainly expressed on T cells and antigen presenting cells and strongly orchestrate adaptive immune responses. Whereas co-stimulatory molecules enhance immune responses, signaling via co-inhibitory molecules dampens the immune system, thereby s...

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Autors principals: Foks, Amanda C., Ran, Ingrid A., Frodermann, Vanessa, Bot, Ilze, van Santbrink, Peter J., Kuiper, Johan, van Puijvelde, Gijs H. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869776/
https://ncbi.nlm.nih.gov/pubmed/24376654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083134
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