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Distinct Signals Mediate Maturation and Allelic Exclusion in Lymphocyte Progenitors
Successful in-frame rearrangement of immunoglobulin heavy chain genes or T cell antigen receptor (TCR) β chain genes in lymphocyte progenitors results in formation of pre-BCR and pre-TCR complexes. These complexes signal progenitor cells to mature, expand in cell number, and suppress further rearran...
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Publicado no: | Immunity |
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Main Authors: | , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
1999
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5310940/ https://ncbi.nlm.nih.gov/pubmed/10403646 |
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