Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8(+) T Cells

NOD mice, a model strain for human type 1 diabetes, express proinsulin (PI) in the thymus. However, insulin-reactive T cells escape negative selection, and subsequent activation of the CD8(+) T-cell clonotype G9C8, which recognizes insulin B15-23 via an αβ T-cell receptor (TCR) incorporating TRAV8-1...

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Detalles Bibliográficos
Publicado en:Diabetes
Main Authors: Pearson, James A., Thayer, Terri C., McLaren, James E., Ladell, Kristin, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly, Morgan, Peter, Wen, Li, Price, David A., Wong, F. Susan
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2016
Assuntos:
Immunology and Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310213/
https://ncbi.nlm.nih.gov/pubmed/26953160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1498
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