Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8(+) T Cells in Type 1 Diabetes

Lymph node stromal cells (LNSC) are essential for providing and maintaining peripheral self-tolerance of potentially autoreactive cells. In type 1 diabetes, proinsulin-specific CD8(+) T cells, escaping central and peripheral tolerance, contribute to β-cell destruction. Using G9Cα(−/−)CD8(+) T cells...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Thayer, Terri C., Davies, Joanne, Pearson, James A., Hanna, Stephanie J., Wen, Li, Wong, F. Susan
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2021
Fag:
Immunology and Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176215/
https://ncbi.nlm.nih.gov/pubmed/33122391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-1050
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