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Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8(+) T Cells in Type 1 Diabetes
Lymph node stromal cells (LNSC) are essential for providing and maintaining peripheral self-tolerance of potentially autoreactive cells. In type 1 diabetes, proinsulin-specific CD8(+) T cells, escaping central and peripheral tolerance, contribute to β-cell destruction. Using G9Cα(−/−)CD8(+) T cells...
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| Publicado no: | Diabetes |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Diabetes Association
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8176215/ https://ncbi.nlm.nih.gov/pubmed/33122391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-1050 |
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