Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8(+) T cells and MHC-II-dependent anergy of CD4(+) T cells. In this study, we show that MHC-II expression on lymph node stromal cells is additionally required for homeostatic maintenance...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Baptista, Antonio P, Roozendaal, Ramon, Reijmers, Rogier M, Koning, Jasper J, Unger, Wendy W, Greuter, Mascha, Keuning, Eelco D, Molenaar, Rosalie, Goverse, Gera, Sneeboer, Marlous M S, den Haan, Joke M M, Boes, Marianne, Mebius, Reina E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270074/
https://ncbi.nlm.nih.gov/pubmed/25407678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04433
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