Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude

For full activation of naïve adaptive lymphocytes in skin-draining lymph nodes (LNs), presentation of peptide:MHC complexes by LN-resident and skin-derived dendritic cells (DCs) that encountered antigens (Ags) is an absolute prerequisite. To get to the nearest draining LN upon intradermal immunizati...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Nadafi, Reza, Koning, Jasper J., Veninga, Henrike, Stachtea, Xanthi N., Konijn, Tanja, Zwiers, Antonie, Malmström, Anders, den Haan, Joke M. M., Mebius, Reina E., Maccarana, Marco, Reijmers, Rogier M.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809438/
https://ncbi.nlm.nih.gov/pubmed/29472931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00206
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