Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis

The epimerization of glucuronic acid into iduronic acid adds structural variability to chondroitin/dermatan sulfate polysaccharides. Iduronic acid-containing domains play essential roles in processes such as coagulation, chemokine and morphogen modulation, collagen maturation, and neurite sprouting....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Stachtea, Xanthi N., Tykesson, Emil, van Kuppevelt, Toin H., Feinstein, Ricardo, Malmström, Anders, Reijmers, Rogier M., Maccarana, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619018/
https://ncbi.nlm.nih.gov/pubmed/26488883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140279
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