Naive CD8(+) T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Basic parameters of the naive antigen (Ag)-specific T-cell repertoire in humans remain poorly defined. Systematic characterization of this ‘ground state' immunity in comparison with memory will allow a better understanding of clonal selection during immune challenge. Here, we used high-definiti...

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Publicado en:Immunol Cell Biol
Main Authors: Neller, Michelle A, Ladell, Kristin, McLaren, James E, Matthews, Katherine K, Gostick, Emma, Pentier, Johanne M, Dolton, Garry, Schauenburg, Andrea JA, Koning, Dan, Fontaine Costa, Ana Isabel CA, Watkins, Thomas S, Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly, Clement, Mathew, Wooldridge, Linda, Cole, David K, van Baarle, Debbie, Sewell, Andrew K, Burrows, Scott R, Price, David A, Miles, John J
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533101/
https://ncbi.nlm.nih.gov/pubmed/25801351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2015.17
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