Naive CD8(+) T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Basic parameters of the naive antigen (Ag)-specific T-cell repertoire in humans remain poorly defined. Systematic characterization of this ‘ground state' immunity in comparison with memory will allow a better understanding of clonal selection during immune challenge. Here, we used high-definiti...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: Neller, Michelle A, Ladell, Kristin, McLaren, James E, Matthews, Katherine K, Gostick, Emma, Pentier, Johanne M, Dolton, Garry, Schauenburg, Andrea JA, Koning, Dan, Fontaine Costa, Ana Isabel CA, Watkins, Thomas S, Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly, Clement, Mathew, Wooldridge, Linda, Cole, David K, van Baarle, Debbie, Sewell, Andrew K, Burrows, Scott R, Price, David A, Miles, John J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533101/
https://ncbi.nlm.nih.gov/pubmed/25801351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2015.17
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