T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

Altered peptide antigens that enhance T-cell immunogenicity have been used to improve peptide-based vaccination for a range of diseases. Although this strategy can prime T-cell responses of greater magnitude, the efficacy of constituent T-cell clonotypes within the primed population can be poor. To...

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Hlavní autoři: Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K., Edwards, Emily S. J., Ladell, Kristin, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J., Price, David A., Wooldridge, Linda, Sewell, Andrew K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481325/
https://ncbi.nlm.nih.gov/pubmed/22952231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.386409
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