Human CD4(+) T Cell Responses to an Attenuated Tetravalent Dengue Vaccine Parallel Those Induced by Natural Infection in Magnitude, HLA Restriction, and Antigen Specificity

Dengue virus (DENV) is responsible for growing numbers of infections worldwide and has proven to be a significant challenge for vaccine development. We previously demonstrated that CD8(+) T cell responses elicited by a dengue live attenuated virus (DLAV) vaccine resemble those observed after natural...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Angelo, Michael A., Grifoni, Alba, O'Rourke, Patrick H., Sidney, John, Paul, Sinu, Peters, Bjoern, de Silva, Aruna D., Phillips, Elizabeth, Mallal, Simon, Diehl, Sean A., Kirkpatrick, Beth D., Whitehead, Stephen S., Durbin, Anna P., Sette, Alessandro, Weiskopf, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309943/
https://ncbi.nlm.nih.gov/pubmed/27974563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02147-16
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