HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus–Specific CD4(+) T-Cell Responses

Background. Each year dengue virus (DENV) infects 400 million human but causes symptomatic disease in only a subset of patients, suggesting that host genetic factors may play a role. HLA molecules that restrict T-cell responses are one of the most polymorphic host factors in humans. Methods. Here we...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Weiskopf, Daniela, Angelo, Michael A., Grifoni, Alba, O'Rourke, Patrick H., Sidney, John, Paul, Sinu, De Silva, Aruna D., Phillips, Elizabeth, Mallal, Simon, Premawansa, Sunil, Premawansa, Gayani, Wijewickrama, Ananda, Peters, Bjoern, Sette, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021234/
https://ncbi.nlm.nih.gov/pubmed/27443615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw309
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