Patterns of Cellular Immunity Associated with Experimental Infection with rDEN2Δ30 (Tonga/74) Support Its Suitability as a Human Dengue Virus Challenge Strain

A deletion variant of the dengue virus (DENV) serotype 2 (DENV2) Tonga/74 strain lacking 30 nucleotides from its 3′ untranslated region (rDEN2Δ30) has previously been established for use in a controlled human DENV challenge model. To evaluate if this model is appropriate for the derivation of correl...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Grifoni, Alba, Angelo, Michael, Sidney, John, Paul, Sinu, Peters, Bjoern, de Silva, Aruna D., Phillips, Elizabeth, Mallal, Simon, Diehl, Sean A., Botten, Jason, Boyson, Jonathan, Kirkpatrick, Beth D., Whitehead, Stephen S., Durbin, Anna P., Sette, Alessandro, Weiskopf, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375662/
https://ncbi.nlm.nih.gov/pubmed/28148797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02133-16
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