Inhibition of DNA and Histone Methylation by 5-Aza-2′-Deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells

Epigenetic alterations play an important role in the development of acute myeloid leukemia (AML) by silencing of genes that suppress leukemogenesis and differentiation. One of the key epigenetic changes in AML is gene silencing by DNA methylation. The importance of this alteration is illustrated by...

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Momparler, Richard L., Côté, Sylvie, Momparler, Louise F., Idaghdour, Youssef
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309231/
https://ncbi.nlm.nih.gov/pubmed/28261562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00019
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