Inhibition of DNA and Histone Methylation by 5-Aza-2′-Deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells

Epigenetic alterations play an important role in the development of acute myeloid leukemia (AML) by silencing of genes that suppress leukemogenesis and differentiation. One of the key epigenetic changes in AML is gene silencing by DNA methylation. The importance of this alteration is illustrated by...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Momparler, Richard L., Côté, Sylvie, Momparler, Louise F., Idaghdour, Youssef
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309231/
https://ncbi.nlm.nih.gov/pubmed/28261562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00019
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