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Inhibition of DNA and Histone Methylation by 5-Aza-2′-Deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells

Epigenetic alterations play an important role in the development of acute myeloid leukemia (AML) by silencing of genes that suppress leukemogenesis and differentiation. One of the key epigenetic changes in AML is gene silencing by DNA methylation. The importance of this alteration is illustrated by...

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發表在:Front Oncol
Main Authors: Momparler, Richard L., Côté, Sylvie, Momparler, Louise F., Idaghdour, Youssef
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309231/
https://ncbi.nlm.nih.gov/pubmed/28261562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00019
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