Epigenetic therapy of acute myeloid leukemia using 5-aza-2'-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation

BACKGROUND: The silencing of tumor suppressor genes (TSGs) by aberrant DNA methylation occurs frequently in acute myeloid leukemia (AML). This epigenetic alteration can be reversed by 5-aza-2’-deoxcytidine (decitabine, 5-AZA-CdR). Although 5-AZA-CdR can induce complete remissions in patients with AM...

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Detalhes bibliográficos
Main Authors: Momparler, Richard L, Côté, Sylvie, Momparler, Louise F, Idaghdour, Youssef
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194463/
https://ncbi.nlm.nih.gov/pubmed/25313314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-6-19
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