Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer

BACKGROUND: The inactivation of tumor suppressor genes (TSGs) by aberrant DNA methylation plays an important role in the development of malignancy. Since this epigenetic change is reversible, it is a potential target for chemotherapeutic intervention using an inhibitor of DNA methylation, such as 5-...

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Main Authors: Lemaire, Maryse, Chabot, Guy G, Raynal, Noël JM, Momparler, Louise F, Hurtubise, Annie, Bernstein, Mark L, Momparler, Richard L
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386792/
https://ncbi.nlm.nih.gov/pubmed/18454857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-128
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