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Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer
BACKGROUND: The inactivation of tumor suppressor genes (TSGs) by aberrant DNA methylation plays an important role in the development of malignancy. Since this epigenetic change is reversible, it is a potential target for chemotherapeutic intervention using an inhibitor of DNA methylation, such as 5-...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2386792/ https://ncbi.nlm.nih.gov/pubmed/18454857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-128 |
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